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Saha et al. BMC Complementary and Alternative Medicine 2013, 13:230 http://biomedcentral/1472-6882/13/RESEARCH ARTICLEOpen AccessCalcarea carbonica induces apoptosis in cancer cells in p53-dependent manner via an immuno-modulatory circuitShilpi Saha1, Dewan Md Sakib Hossain1, Shravanti Mukherjee1, Suchismita Mohanty1, Minakshi Mazumdar1, Sanhita Mukherjee2, Uttam K Ghosh1, Chaturbhuj Nayek3, Chinta Raveendar3, Anil Khurana3, Rathin Chakrabarty4, Gaurisankar Sa1* and Tanya Das1*AbstractBackground: Complementary medicines, which includes homeopathy, are utilised by numerous individuals with cancer, ordinarily alongside with traditional treatment. Having said that, the molecular mechanisms underneath the anti-cancer effect, if any, of these medicines have still remained unexplored. To this finish we attempted to evaluate the efficacy of calcarea carbonica, a homeopathic medicine, as an anti-cancer agent and to delineate the detail molecular mechanism(s) underlying calcerea carbonica-induced tumor regression. Methods: To investigate and delineate the underlying mechanisms of calcarea carbonica-induced tumor regression, Trypan blue dye-exc.